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EXO Balm
Exosome Post-Care Optimizing Balm
Exosome Regenerative Complex
For Skin
Exosome Regenerative Complex+
For Skin & Scalp
Publications
Clinical Cases
Worldwide Patents
Research and Development
SCIENCE & TECHNOLOGY
What are Exosomes?
BENEV Exosome treatments are based on the most cutting edge scientific biotech breakthrough for skin rejuvenation and regeneration. Exosomes are responsible for cell to cell communication and for facilitating the exchange of RNA and other important proteins between cells (e.g. fibroblasts, keratinocytes, immune cells, etc.), in addition to transferring numerous growth factors and cytokines and genetic materials that have shown signs of tissue repair and improving skin cells. These data coding avatars have been harnessed for our new line of exosome products to promote a more radiant youthful appearance.
Why BENEV Exosomes?
POWERED BY EXOSCRT™
Exosomes, an 30~200 nm endoplasmic reticulum that is secreted for cell-to-cell communication, plays an important role in influencing the microenvironment around cells, ExoSCRT™ is an innovative technology to separate and refine 0.1~0.5% pure exosomes from stem cells and helps the virtualization of natural skin energy by affecting skin cells effectively.
IN VITRO TESTING
Human Fibroblast Cell Proliferation
BENEV Exosome products powered by ExoSCRT™ promote skin cell proliferation by up to 80% in a dose-dependent manner. ExoSCRT™ 3 µg/ml 36.1% increase, ExoSCRT ™ 6 µg/ml 84.0% increase, compared against positive control (1% GS).
Human Fibroblast Cell Proliferation
BENEV Exosome products powered by ExoSCRT ™ may increase the elastin amount of human dermal fibroblasts up to 300% in vitro.
Collagen Increased By ExoSCRT ™
After delivery of BENEV Exosome products powered by ExoSCRT ™ into fibroblasts, neocollagenesis can increase up to 6 folds.
Cellular Uptake of Exosomes By ExoSCRT™
Human skin cells easily uptake BENEV products powered by ExoSCRT ™ which means that stem cell-derived exosomes can message skin cells to “Do Something”.
IN VIVO TESTING
Exosomes are nano-sized vesicles (30–200 nm) constantly released by almost all cells. The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids, makes them an appealing cell-free therapy option to treat multiple diseases. Here, we investigated for the first time whether human adipose tissue-derived mesenchymal stem cell-derived exosomes can ameliorate atopic dermatitis (AD) in an in vivo mouse model. When injected either intravenously (IV) or subcutaneously (SC) into NC/Nga mice treated with house dust mite antigens, ERC-exosomes were found to reduce pathological symptoms such as clinical score, the levels of serum IgE, the number of eosinophils in blood, and the infiltration of mast cells, CD86+, and CD206+ cells in skin lesions. ERC-exosomes also significantly reduced mRNA expression of various inflammatory cytokines such as interleukin (IL)-4, IL-23, IL-31, and tumor necrosis factor (TNF-) in AD skin lesions of Nc/Nga mice. Taken together, these results suggest that ERC-exosomes can be a novel promising cell-free therapeutic modality for AD treatment. (Byong Seung Cho, Jin Ock Kim, Dae Hyun Ha and Yong Weon - Stem Cell Research Therapy, BioMedCentral.com)
Disclaimer:
United States customers only.
BENEV Exosome Products are post care “topical use” cosmetic solutions. The isolated and purified exosomes in both products have been accepted by the PCPC, and International Cosmetic Ingredient Nomenclature Committee (INC), and the name ‘Human Adipose Stromal Cell Exosomes’ was given and published in the International Cosmetic Ingredient Dictionary and Handbook, known as INCI book. There are at this time no other cosmetic INCI name(s) assigned to exosome products in the market prior to this accomplishment. These products are not drug products. They are not intended to prevent, treat or cure diseases or medical conditions. They are not intended to be injected or delivered intravenously.
TESTIMONIALS
BEFORE AND AFTERS
Patient trial photos (Mei Vu™) were taken before and after a 3 - 5 Clinical Study featured BENEV Exosome Regenerative Complex powered by ExoSCRT TM. Participants experienced no irritation, and all patients reported that they felt and saw a noticeable and immediate difference in the overall appearance of their skin after just the first treatment, with full results after the 3rd-5th treatment.
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EXOSOME KEY OPINION LEADERS
