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SCIENCE AND TECHNOLOGY

WHAT ARE EXOSOMES ?

BENEV Exosome treatments are based on the most cutting edge scientific biotech breakthrough for skin rejuvenation and regeneration. Exosomes are responsible for cell to cell communication and for facilitating the exchange of RNA and other important proteins between cells (e.g. fibroblasts, keratinocytes, immune cells, etc.), in addition to transferring numerous growth factors and cytokines and genetic materials that have shown signs of tissue repair and improving skin cells. These data coding avatars have been harnessed for our new line of exosome products to promote a more radiant youthful appearance.

WHAT IS EXOSCRT™ ?

Exosome, an 30~200 nm endoplasmic reticulum that is secreted for cell-to-cell communication, plays an important role in influencing the microenvironment around cells, ExoSCRT™ is an innovative technology to separate and refine 0.1% pure exosomes from stem cells and helps the virtualization of natural skin energy by affecting skin cells effectively.

BENEV X-RATED EXOSOMES TREATMENT™

BENEV X-RATED EXOSOMES TREATMENT™  feature BENEV Exosome Regenerative Complex and Exosome Regenerative Complex + powered by Exo-SCRT™, the most cutting edge scientific biotech breakthrough for clinically proven skin and scalp rejuvenation and regeneration available, harnessing the power of STEM CELL DERIVED LYOPHILIZED EXOSOMES potent GROWTH FACTORS, PEPTIDES, COENZYMES, MINERALS, AMINO ACIDS, and VITAMINS. 

CLINICALLY PROVEN TO IMPROVE THE APPEARANCE OF:

Fine Lines, Wrinkles, and age spots

Overall brightness and hydration

Redness and skin irritation

Skin lesions and scars

Texture and pore size

 
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IN VITRO TESTING

 
 

HUMAN FIBROBLAST CELL PROLIFERATION

Exosome Regenerative Complex powered by ExoSCRT™ promotes skin cell proliferation by up to 80% in a dose-dependent manner. Exosome Regenerative Complex powered by ExoSCRT™ 3 µg/ml 36.1% increase, Exosome Regenerative Complex powered by ExoSCRT ™ 6 µg/ml 84.0% increase, compared against positive control (1% GS).    

ELASTIN INCREASEAD BY ExoSCRT ™

Exosome Regenerative Complex powered by ExoSCRT ™ may increase the elastin amount of human dermal fibroblasts up to 300% in vitro. 

 

COLLAGEN INCREASEAD BY ExoSCRT ™

After delivery of BENEV Exosome Regenerative Complex™ powered by ExoSCRT ™ into fibroblasts, neocollagenesis can increase up to 6 folds.

CELLULAR UPTAKE OF EXOSOMES

Human skin cells easily uptake BENEV Exosome Regenerative Complex™ powered by ExoSCRT ™ which means that stem cell-derived exosomes can message skin cells to “Do Something”.

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IN VIVO TESTING

 
 
 

Exosomes are nano-sized vesicles (30–200 nm) constantly released by almost all cells.

The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids, makes them an appealing cell-free therapy option to treat multiple diseases. Here, we investigated for the first time whether human adipose tissue-derived mesenchymal stem cell-derived exosomes (ERC-exosomes) can ameliorate atopic dermatitis (AD) in an in vivo mouse model. When injected either intravenously (IV) or subcutaneously (SC) into NC/Nga mice treated with house dust mite antigens, ERC-exosomes were found to reduce pathological symptoms such as clinical score, the levels of serum IgE, the number of eosinophils in blood, and the infiltration of mast cells, CD86+, and CD206+ cells in skin lesions. ERC-exosomes also significantly reduced mRNA expression of various inflammatory cytokines such as interleukin (IL)-4, IL-23, IL-31, and tumor necrosis factor  (TNF-) in AD skin lesions of Nc/Nga mice. Taken together, these results suggest that ERC-exosomes can be a novel promising cell-free therapeutic modality for AD treatment. (Byong Seung Cho, Jin Ock Kim, Dae Hyun Ha and Yong Weon - Stem Cell Research Therapy, BioMedCentral.com)

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UPCOMING EVENTS

 
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TREATMENT BENEFITS

COMPARISON CHART

 
 

EXOSOME
REGENERATIVE COMPLEX

2.5 BILLION

Lyophilixed Exosomes

INTENSIVE DUAL-ACTION

CLINICALLY PROVEN

EXOSOME
REGENERATIVE COMPLEX +

COMING SOON 2021

VS

 
 
 
 

5 BILLION

Lyophilixed Exosomes

INTENSIVE DUAL-ACTION

CLINICALLY PROVEN

MORE POWERFUL

MORE POTENT

FASTER RESULT

 
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Increases skin elasticity, firmness, & tone

Peptides

Reduce fine line, wrinkles,& age spots

Growth Factors

Reduce redness & skin irritation

Palmitoyl Pentapeptide-4

Promotes more collagen & elastin production

Peptides

Reduce fine line, wrinkles,& age spots even more

Growth Factors

Stimulate cell growth, prolifiation, & healing

Human Adipose Stromal Cell Exosome

Reduce hair-loss & increase hair growth

Growth Factors

Nourish skin & hair

Amino Acids

Fight pigmentation & protect against sun damage

Vitamins

 
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SERVICE MENU

EXOSOMES the Next Small Thing ... Nanoparticles Offering A New Future.

The Generation of Regenerative is X-Rated featuring EXOSOME REGENERATIVE COMPLEX

SCIENCE HAS NEVER LOOKED SEXIER

BENEV X-RATED EXOSOME TREATMENT™ features BENEV Exosome Regenerative Complex and Exosome Regenerative Complex + powered by Exo-SCRTTM, the most cutting edge scientific biotech breakthrough for clinically proven skin and scalp rejuvenation and regeneration available, harnessing the power of STEM CELL DERIVED LYOPHILIZED EXOSOMES potent GROWTH FACTORS, PEPTIDES, COENZYMES, MINERALS, AMINO ACIDS, and VITAMINS. 

X-RATED EXOSOME TREATMENT™ 

X-RATED EXOSOME TREATMENT™  with Micro Needle

X-RATED EXOSOME TREATMENT™  with Non-Invasive Laser

X-RATED EXOSOME TREATMENT™  with RF Needling

X-RATED EXOSOME TREATMENT™  with PRP

X-RATED EXOSOME TREATMENT™  with Chemical Peel

BENEV X-RATED EXOSOME TREATMENT™ are INTIMATELY YOURS, ask your medical skincare professional how BENEV Exosome Regenerative Complex and Exosome Regenerative Complex + powered by Exo-SCRT can integrate into all of your procedures for unsurpassed results.

 
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EXOSOME REGENERATIVE COMPLEX

POWERED by ExoCoBio's ExoSCRT™

Exosome Regenerative Complex is an intensive dual-action complex formulated to absorb quickly into the skin delivering the concentrated power over 2.5 BILLION STEM CELL DERIVED LYOPHILIZED EXOSOMES, potent GROWTH FACTORS, PEPTIDES, COENZYMES, MINERALS, AMINO ACIDS, and VITAMINS. Our paraben-free, steroid-free, and hypoallergenic patented technologies and ingredients are clinically proven to rejuvenate and regenerate the skin.

 

2.5 BILLION

Lyophilized Exosomes

BEFORE & AFTER

FOR AGING SKIN

Aging Skin

Firm Skin

Female | 57

Fitzpatrick 2

Modality: (GF-EX) ® Post RF Needling

96.4% of patients noticed a decrease in fine lines, wrinkles and age spots after just 5 treatments, and 89.6% of patients showed results after just the 3rd treatment.

FOR DULL DEHYDRATED SKIN

Dull Dehydrated Skin

Radiant Hydrated Skin

Female | 49

Fitzpatrick 3

Modality: (GF-EX)® Post Micro Needling

98.1% of patients stated that their overall complexion appeared to be brighter and more hydrated after just 5 treatments, and 94.7% of patients showed results after just the 3rd treatment.

FOR SENSITIVE SKIN

Sensitive Skin

Calm Skin

Female | 53

Fitzpatrick 3

Modality: (GF-EX) ® Post Micro Needling

87.3% of patients reported a reduction in redness and skin irritation after just 3 treatments,  and 82.4% of patients stated their skin felt and looked calmer after the 2nd treatment.

FOR PROBLEMATIC SKIN

Problem Skin

Clean Skin

Female | 28

Fitzpatrick 2

Modality: (GF-EX) ® Post Chemical Peel

91.7% of patients reported a reduction in lesions and scars after just 3 treatments, and 88.2% of patients showed results after just the 2nd treatment.

FOR UNEVEN TEXTURE & ENLARGED PORES

Uneven Texture & Enlarged Pores

Smooth Skin Minimized Pores

Female | 36

Fitzpatrick 3

Modality: (GF-EX) ® Post Non Invasive Laser

92.6% of patients reported the texture of their skin improved, including the size of their pores after just 3 treatments,  and 90.9% of patients showed results after just the 2nd treatment.

* Patient trial photos (Mei VuTM) were taken before and after a 3 - 5 XIRATED treatment Clinical Study featuring BENEV Exosome Regenerative Complex powered by Exo-SCRTTM. Participants experienced no irritation, and all patients reported that they felt and saw a noticeable and immediate difference in the overall appearance of their skin after just the 1st treatment, with full results after the 3rd-5th treatment.

POST MICRO NEEDLING

Before

After

Female | 28

Photo Provided by:

Dr. Diane Duncan .,MD.,F.A.C.S

POST ERBIUM LASER

Before

After

Female | 58

Photo Provided by:

Dr. Diane Duncan .,MD.,F.A.C.S

PROCEDURE BASED RESULTS

POST PLASMA

Before

After

Female | 57

Photo Provided by:

Dr. Diane Duncan .,MD.,F.A.C.S

 
 
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EXOSOME REGENERATIVE COMPLEX +

POWERED by ExoCoBio's ExoSCRT™

More Powerful. More Potent. Faster Results.

Our clinically proven paraben free and hypoallergenic intensive dual action complex is designed to absorb quickly into the skin delivering the concentrated power of oer 5 billion lyophilized exosomes, potent growth factors, peptides, coenzymes, minerals, amino acids, vitamins and irritation reduction agents to rejuvenate, and intensely moisturize the skin and scalp. 

 

5 BILLION

Lyophilized Exosomes