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Elevated Expressions



Fast Acting

Improvements as early as 24 hours

Safety Profile

Well Established Safety Profile


Long Lasting Improvement


High Subject Satisfaction


Letybo Was Proven To Be Effective


Approved In



Trusted by





*Based on total number of sales globally.

1. Data on file. List of approved countries (toxin and filler). Hugel; 2023. 2. Hugel annual report 2021. Hu gel. Accessed April 12, 2023. board=Y&bo_table=annual&file_name=b_file_1664364528wcxsosaovw.pdf&o_file_name=hugel_ar_2021_en.pdf 3. Data on file. Total toxin sales 2010-2022. Hugel; February 23, 2023.

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Just like any medical decision, consult with your healthcare provider to determine if LETYBO is right for you








Temporarily improve moderate to severe glabellar frown lines in adults, which are the vertical frown lines between your eyebrows.






  • How Dose It Feel?
    The feeling is described by most patients as comfortable with no pain, only a slight tingling sensation with light pressure. Based on the depth and area treated this feeling can vary.
  • How Many Treatments Do I Need?
    Most physicians find that three to six treatments, spaced four to six weeks apart provide the optimal experience and outcome for patients.
  • How Long Does The Treatment Take?
    The actual treatment takes about 20 - 45 min depending on the area to be treated.
  • How Long Do The Result Last?
    Everyone is different, but the collagen you make is your own and continues accelerated production over three months.
  • Dual Wave Radio Frequency Microneedling System
    The world's first & only FDA cleared Pulsed Wave & Continuous Wave Radio Frequency Microneedling device for ultimate skin complexion and skin revitalization. Sylfirm X has proven its effectiveness and safety through 25+ clinical studies and experiments.
  • What Is Radio Frequency?
    Radio Frequency provides heat that stimulates collagen production, which has been found to lead to tighter, younger-looking skin. Combined with state-of-the-art microneedling patients experience optimal results.

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*This site is intended for the US residents only.

Letybo Disclaimer

LETYBO® (letibotulinumtoxinA-wlbg) Injection: Botulinum toxin type A neurotoxin complex (100 Units)

Approved Indication: LETYBO® is a prescription medicine that is injected into muscles and used in adults to temporarily improve the look of moderate to severe frown lines between the eyebrows (glabellar lines)


IMPORTANT SAFETY INFORMATION for LETYBO® (letibotulinumtoxinA-wlbg) Injection 

LETYBO® may cause serious side effects that can be life threatening. Get medical help right away if you have any of these problems after treatment with LETYBO®:  

  • Problems swallowing, speaking, or breathing, due to weakening of associated muscles can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months.  

  • Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms that include loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, and trouble swallowing.  

Do not receive LETYBO® if you are allergic to any of the ingredients in LETYBO® (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as MYOBLOC® (rimabotulinumtoxinB), BOTOX®/BOTOX® COSMETIC (onabotulinumtoxinA), DYSPORT® (abobotulinumtoxinA), XEOMIN® (incobotulinumtoxinA), JEUVEAU® (prabotulinumtoxinA-xvfs), or DAXXIFY® (daxibotulinumtoxinA-lanm); or have a skin infection at the planned injection site; or are a child.  

LETYBO® dosing units are not the same as, or comparable to, any other botulinum toxin product. 

Tell your healthcare provider about all your medical conditions, including side effects from botulinum toxin products, including dry eye; breathing, swallowing, bleeding, or heart problems; plans to have surgery; weakness of forehead muscles, drooping eyelids; have had surgery on your face; are pregnant or breastfeeding or plan to become pregnant or breastfeed.  

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. 

Especially tell your healthcare provider if you have received any other botulinum toxin product in the last 4 months or any in the past, and exactly which product you received (such as MYOBLOC®, BOTOX®/BOTOX® Cosmetic, DYSPORT®, XEOMIN®, JEUVEAU® or DAXXIFY®). LETYBO® may cause serious side effects, including allergic reactions (such as itching, rash, hives, wheezing, trouble breathing, or dizziness or feeling faint), heart problems (such as irregular heartbeat and heart attack), and eye problems (including dry eye, reduced blinking, and corneal problems). Tell your healthcare provider or get help right away if you experience a serious side effect. No serious side events of distant spread of toxin effect associated with dermatologic use of LETYBO® have been reported in clinical studies at the dose of 20 Units for glabellar lines. The most common side effect of LETYBO® was headache. 


See full prescribing information for complete boxed warning. The effects of all botulinum toxin products, including LETYBO, may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. LETYBO is not approved for the treatment of spasticity or any conditions other than glabellar lines. (5.1)


These are not all the possible side effects of LETYBO®. For more information, see the full Prescribing Information including Boxed Warning, and refer to the Medication Guide or talk with your doctor. To report side effects associated with LETYBO®, please call 1-949-457-2222. You may also report side effects to the FDA at 1-800-FDA-1088 or visit


The Product Information is also available by calling us at 949-457-2222. BLA # 761225 / Reference ID #5337801

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