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SCIENCE AND TECHNOLOGY

WHAT ARE EXOSOMES ?

BENEV Exosome treatments are based on the most cutting edge scientific biotech breakthrough for skin rejuvenation and regeneration. Exosomes are responsible for cell to cell communication and for facilitating the exchange of RNA and other important proteins between cells (e.g. fibroblasts, keratinocytes, immune cells, etc.), in addition to transferring numerous growth factors and cytokines and genetic materials that have shown signs of tissue repair and improving skin cells. These data coding avatars have been harnessed for our new line of exosome products to promote a more radiant youthful appearance.

WHAT IS EXOSCRT™ ?

Exosome, an 30~200 nm endoplasmic reticulum that is secreted for cell-to-cell communication, plays an important role in influencing the microenvironment around cells, ExoSCRT™ is an innovative technology to separate and refine 0.1% pure exosomes from stem cells and helps the virtualization of natural skin energy by affecting skin cells effectively.

BENEV XIRATED EXOSOME FACIAL™ treatments feature BENEV Exosome Regenerative Complex Powered by ExoSCRT™, Each XIRATED EXOSOME FACIAL™ harnesses the power of over 2BILLION + LYOPHILIZED EXOSOMES

CLINICALLY PROVEN TO IMPROVE THE APPEARANCE OF:

Fine Lines, Wrinkles, and age spots

Overall brightness and hydration

Redness and skin irritation

Skin lesions and scars

Texture and pore size

 
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IN VITRO TESTING

 
 

HUMAN FIBROBLAST CELL PROLIFERATION

Exosome Regenerative Complex powered by ExoSCRT™ promotes skin cell proliferation by up to 80% in a dose-dependent manner. Exosome Regenerative Complex powered by ExoSCRT™ 3 µg/ml 36.1% increase, Exosome Regenerative Complex powered by ExoSCRT ™ 6 µg/ml 84.0% increase, compared against positive control (1% GS).    

ELASTIN INCREASEAD BY ExoSCRT ™

Exosome Regenerative Complex powered by ExoSCRT ™ may increase the elastin amount of human dermal fibroblasts up to 300% in vitro. 

 

COLLAGEN INCREASEAD BY ExoSCRT ™

After delivery of BENEV Exosome Regenerative Complex™ powered by ExoSCRT ™ into fibroblasts, neocollagenesis can increase up to 6 folds.

CELLULAR UPTAKE OF EXOSOMES

Human skin cells easily uptake BENEV Exosome Regenerative Complex™ powered by ExoSCRT ™ which means that stem cell-derived exosomes can message skin cells to “Do Something”.

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IN VIVO TESTING

 
 
 

Exosomes are nano-sized vesicles (30–200 nm) constantly released by almost all cells.

The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids, makes them an appealing cell-free therapy option to treat multiple diseases. Here, we investigated for the first time whether human adipose tissue-derived mesenchymal stem cell-derived exosomes (ERC-exosomes) can ameliorate atopic dermatitis (AD) in an in vivo mouse model. When injected either intravenously (IV) or subcutaneously (SC) into NC/Nga mice treated with house dust mite antigens, ERC-exosomes were found to reduce pathological symptoms such as clinical score, the levels of serum IgE, the number of eosinophils in blood, and the infiltration of mast cells, CD86+, and CD206+ cells in skin lesions. ERC-exosomes also significantly reduced mRNA expression of various inflammatory cytokines such as interleukin (IL)-4, IL-23, IL-31, and tumor necrosis factor  (TNF-) in AD skin lesions of Nc/Nga mice. Taken together, these results suggest that ERC-exosomes can be a novel promising cell-free therapeutic modality for AD treatment. (Byong Seung Cho, Jin Ock Kim, Dae Hyun Ha and Yong Weon - Stem Cell Research Therapy, BioMedCentral.com)

UPCOMING EVENTS

 
Breakthroughs in Aesthetics: Live Exclusive Unveiling of Exosome Regenerative Complex +
Apr 06, 12:00 PM PDT
Online seminar
 

TREATMENT BENEFITS

COMPARISON CHART

 
 

EXOSOME
REGENERATIVE COMPLEX

2.5 BILLION

Lyophilixed Exosomes

INTENSIVE DUAL-ACTION

CLINICALLY PROVEN

EXOSOME
REGENERATIVE COMPLEX +

COMING SOON 2021

VS

 
 
 
 

5 BILLION

Lyophilixed Exosomes

INTENSIVE DUAL-ACTION

CLINICALLY PROVEN

MORE POWERFUL

MORE POTENT

FASTER RESULT

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Increases skin elasticity, firmness, & tone

Peptides

Reduce fine line, wrinkles,& age spots

Growth Factors

Reduce redness & skin irritation

Palmitoyl Pentapeptide-4

Promotes more collagen & elastin production

Peptides

Reduce fine line, wrinkles,& age spots even more

Growth Factors

Stimulate cell growth, prolifiation, & healing

Human Adipose Stromal Cell Exosome

Reduce hair-loss & increase hair growth

Growth Factors

Nourish skin & hair

Amino Acids

Fight pigmentation & protect against sun damage

Vitamins

 
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SERVICE MENU

 
 
 
 
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EXOSOME REGENERATIVE COMPLEX

POWERED by ExoCoBio's ExoSCRT™

Exosome Regenerative Complex is an intensive dual-action complex formulated to absorb quickly into the skin delivering the concentrated power over 2.5 BILLION STEM CELL DERIVED LYOPHILIZED EXOSOMES, potent GROWTH FACTORS, PEPTIDES, COENZYMES, MINERALS, AMINO ACIDS, and VITAMINS. Our paraben-free, steroid-free, and hypoallergenic patented technologies and ingredients are clinically proven to rejuvenate and regenerate the skin.

 

2.5 BILLION

Lyophilixed Exosomes

BEFORE & AFTER

 
 
 
 
 
 
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EXOSOME REGENERATIVE COMPLEX +

POWERED by ExoCoBio's ExoSCRT™

More Powerful. More Potent. Faster Results.

Our clinically proven paraben free and hypoallergenic intensive dual action complex is designed to absorb quickly into the skin delivering the concentrated power of oer 5 billion lyophilized exosomes, potent growth factors, peptides, coenzymes, minerals, amino acids, vitamins and irritation reduction agents to rejuvenate, and intensely moisturize the skin and scalp. 

 

5 BILLION

Lyophilixed Exosomes

BEFORE & AFTER

 
 
 
 
PATTERN HAIR LOSS

Before

After

Male | 40's 

  • Protocol: 2 weeks interval, 6 sessions 

  • Improvement on the “M” hairline and overall hair loss, alleviation on the hair loss of the top of the head

Before

After 

Male | 40's

  • Protocol: 1 week interval, 5 sessions

  • Improvement on the overall hair loss and that of the top of the head

  • Clinical conducted by : Dr. Chang Ro Lee, Leo Clinic

Before

After 5th treatment

Female | 30's

  • Protocol: 1 week interval, 5 sessions

  • Improvement on the hair loss of the top of the head and overall scalp health after 2 sessions

  • Clinical conducted by : Dr. Hwang HeuiLee, Cheongdam NB Clinic

Before

After

Female | 30's

  • Protocol : 1 month interval, 6 sessions of treatments

  • Clinical conducted by : Dr. Inigo De Felipe

DHT HAIR LOSS

Before

After 

Male

  • Protocol: 1 month interval

  • Effective in the hair loss (Hair Restoration)

  • Clinical conducted by : Pure Vanity Spa

FRONTAL FIBROSING ALOPECIA
 

Before

After 

Male 

  • Protocol : 1 month interval, 6 sessions of treatments

  • Clinical conducted by : Dr. Inigo De Felipe 

Before

After 5th treatment

Female | 20's 

  • Protocol: 1 week interval, 5 sessions

  • Improvement on the overall hair loss and that of the top of the head

  • Clinical conducted by : Dr. Chang Ro Lee, Leo Clinic

HEREDITARY PATTERN HAIR LOSS

Before

After 5th treatment

Female | 20's 

  • Protocol: 1 week interval, 5 sessions

  • Improvement of hairline and growth of baby hair on the top of the head

  • Clinical conducted by : Dr. Hwang HeuiLee, Cheongdam NB Clinic

HAIR LOSS CAUSED BY AGING

Before

After 8th treatment

Male | 50's

  • Protocol : 2 weeks interval,8 sessions, 

  • Improvement of hair loss, improvement of hair strength

  • Clinical conducted by: Dr. Hwang HeuiLee, Cheongdam NB Clinic

  • The patient took Avodart.

Before

After 8th treatment

Male | 60's

  • Protocol : 2 weeks interval, 8 sessions, 

  • Improvement of hair loss 

  • Clinical conducted by: Dr. Hwang HeuiLee, Cheongdam NB Clinic

  • The patient did not take any medication for hair loss

Before

After 5h treatment

Male | 70's

  • Protocol : 2 weeks interval, 5 sessions, 

  • Improvement of hair loss, increase in the strength of hair

  • Clinical conducted by: Dr. Hwang HeuiLee, Cheongdam NB Clinic

  • The patient did not take any medication for hair loss

  • The patient also took PRP treatment in 2 weeks interval

Before

After 5th treatment

Male | 50's

  • Protocol: 1 month interval, 5 sessions 

  • Improvement on the hair loss, increase in the strength of hair

  • Clinical conducted by: Dr. Steven HoseongYang, MD, PhD, Guam Dermatology Institute

Before

After 

Male | 40's

  • Protocol: 2 sessions of treatments (a day before the hair implantation & during the hair implantation)

  • Patient’s satisfaction index : 10 (out of 10). Product was applied on where hair was collected, and it has improved bleeding and redness

  • Clinical conducted by : Dr. Asli Berker

Before

After 

Male | 50's

  • Protocol: 3 sessions of treatments with 2 weeks interval 

  • Patient’s satisfaction index : 6 (out of 10). Product has significantly helped improve the seborrheic dermatitis of the scalp and alleviated the hair loss.

  • Clinical conducted by : Dr. Asli Berker

Before

After 

Male | 20's

  • Protocol: 2 sessions of treatments with 15 days interval 

  • Patient’s satisfaction index : 8 (out of 10). Product has helped alleviate the hair loss and strengthened the scalp.

  • Clinical conducted by : Dr. Asli Berker

Before

After 

Male | 30's

  • Protocol: 2 sessions of treatments with 15 days interval (before & after the hair implantation)

  • Patient’s satisfaction index : 8 (out of 10). Product helped increase the engraftment rate and decreased the downtime.

  • Clinical conducted by : Dr. Asli Berker

HAIR LOSS CAUSED BY HYPOCUPREMIA & ANEMIA
 

Before